The Via Flaminia, since the days b.C, crossed the Arno in this point. Florence was then a little village in the surroundings, not the most important one.
It's sited on the Piazza del Duomo, number 9. It houses diverse pieces and materials, among them some of the elements Brunelleschi used to construct the dome.
If the Duomo is the religious centre, the Piazza della Signoria is the political one, where the Vecchio Palace, the Uffizi Palace and the Loggia are sited.
In front of the Palazzo Vecchio the tourist will find a building of proud semi-circular arches, from the 14th-century, place for the old Signoria's activities.